Abstract #2185

Assessment of Microcirculation in Murine Myocardium: A Retrospective Method for Quantification of Perfusion and Regional Blood Volume

Fabian Tobias Gutjahr¹, Thomas Kampf¹, Xavier Helluy¹, Christian Herbert Ziener², Peter M. Jakob¹,³, Wolfgang Rudolf Bauer⁴

¹Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; ²German Cancer Research Center, Heidelberg, Baden Wuerttemberg, Germany; ³Magnetic Resonance Bavaria, Wuerzburg, Bavaria, Germany; ⁴Medizinische Klinik und Polyklinik I, Universitaetsklinikum Wuerzburg, Wuerzburg, Bavaria, Germany

In this work a retrospectively triggered method for the quantification of perfusion and regional blood volume (RBV) in murine myocardium is demonstrated. Perfusion and RBV maps can be reconstructed on any desired position in the heart cycle. Furthermore the calculation of RBV maps requires a voxel by voxel comparison of a pre and post contrast agent T₁ map. A good match for both map can be guaranteed due to the ability to reconstruct T₁ maps of any desired position in the heart cycle.