Abstract #1548

T2 Mapping and Diffusion Weighted Imaging for Quantification of Acute and Chronic Renal Pathology Following Acute Kidney Injury in Mice Comparison with Histopathology

Katja Hueper¹, Martin Meier², Marcel Gutberlet¹, Song Rong³, Xia Lu⁴, Hermann Haller³, Frank Wacker¹, Dagmar Hartung¹, Faikah Gueler³

¹Radiology, Hannover Medical School, Hannover, Germany; ²Institute of Animal Science, Hannover Medical School, Hannover, Germany; ³Nephrology, Hannover Medical School, Hannover, Germany; ⁴Zunyi Medical College, Wuhan, China

We investigated whether T2mapping and diffusion weighted imaging (DWI) allow monitoring renal pathology after ischemia induced acute kidney injury (AKI) in mice. T2-changes after AKI were most pronounced in the outer medulla. T2-increase was significantly higher after severe than after moderate AKI and correlated with kidney volume loss at d28. ADC was significantly reduced after AKI till d28 and ADC-reduction was more pronounced after severe AKI. Correspondingly, fibrosis and inflammatory cell infiltration were higher after severe than after moderate AKI. Thus, T2mapping and DWI may help to non-invasively determine presence and severity of acute and chronic changes after AKI.