Yi Xin1,
Maurizio Cereda2, Jessie Huang1, Harrilla Profka1,
Biao Han1, Jennia Rajaei1, Stephen J. Kadlececk1,
Clifford Deutschman2, Rahim Rizi1
1Department
of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department
of Anesthesiology and Critical Care, University of Pennsylvania,
Philadelphia, PA, United States
Ventilator induced lung injury (VILI) is an iatrogenic entity that increases mortality in ventilated patients and is caused by regional tissue deformation and stress. However, there is a paucity of instruments that are able to non-invasively quantify the regional effects of lung injury. Using hyperpolarized MRI, we identified regional increases in airspace dimensions and fractional ventilation after the induction of VILI in ventilated rats. These findings may reflect a propensity to focal injury and suggest that hyperpolarized MRI may have a role in the identification of VILI and the assessment of responses to lung protective strategies.