Masaru Ishii1,
Hooman Hamedani2, Stephen J. Kadlececk2, Kiarash Emami2,
Yi Xin2, Milton Rossman3, Rahim Rizi2
1Otolarynology,
Johns Hopkins Medical Center, Baltimore, MD, United States; 2Department
of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Pulmonary,
allergy and Critical Care Division, University of Pennsylvania, Philadelphia,
PA, United States
In this work we present the first large-scale short-term lung gas exchange imaging reproducibility study using Hyperpolarized 3He. We estimated the short-time reproducibility of regional pAO2 measurements in asymptomatic smokers and non-smokers and found that the repeatability is similar in two groups and is a strong function of measurement noise. We also showed that asymptomatic smokers, while appearing normal from the physical exam and PFT standpoint, show demonstrable difference in temporal and spatial imaging characteristics.