Octavia Bane1,
2, Daniel C. Lee3, Brandon C. Benefield3,
Kathleen R. Harris1, Neil R. Chatterjee, 23, James C.
Carr1, Timothy J. Carroll1, 2
1Radiology,
Northwestern University, Chicago, IL, United States; 2Biomedical
Engineering, Northwestern University, Evanston, IL, United States; 3Medicine,
Northwestern University, Chicago, IL, United States
We sought to determine the compartmentalization of the blood pool agent gadofosveset and the effect of its transient binding to albumin on the quantification of steady-state fractional myocardial blood volume (fMBV). Simulations of the transient binding of gadofosveset to albumin, and fMBV measurements in healthy volunteers with gadofosveset and in a canine subject with a USPIO contrast agent were performed. The distribution of the volunteer data indicates that a three-compartment model, with slow exchange of gadofosveset and water protons between the vascular and interstitial compartments, and fast water exchange between the interstitium and the myocytes, is appropriate.