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Abstract #0964

Investigation of Vascular MRI (ASL and SWI) in Complement to RANO Criteria to Characterize Anti-Angiogenic Therapeutic Response of Glioblastomas

Slim Fellah1, Olivier Chinot2, Nadine Girard1, 3, Maxime Guye4, Virginie Callot5

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), CNRS / Aix-Marseille Universit, Marseille , France; 2Service de Neurochirurgie, Hpital de la Timone, AP-HM, Marseille, France; 3Service de Neuroradiologie, Hpital de la Timone, AP-HM, Marseille, France; 4Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), CNRS / Aix-Marseille Universit, Marseille, France; 5Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), Aix-Marseille University, Marseille , France


In this study, we performed longitudinal MR follow-up of GBM treated with anti-angiogenics using a multimodal MR protocol. The investigations particularly involved arterial spin-labeling (ASL) and susceptibility weighted imaging (SWI). Both sequences provide vascular information that may be particularly appropriated to evaluate the anti-angiogenic response, in complement to RANO criteria.