Benjamin Leporq1,
Arnaud Le Troter2, Yann Le Fur2, Emmanuelle Salort-Campana3,
Patrick J. Cozzone2, Olivier Beuf4, David Bendahan2
1CREATIS;
CNRS UMR 5220; INSERM U1044; INSA-Lyon; UCBL
, Universit de Lyon, Villeurbanne, Rhone-Alpes, France; 2CRMBM;
CNRS UMR 6612, Aix-Marseille Universit, Marseille, PACA, France; 3Reference
Center for Neuromuscular Disorders, Timone Hospital, Assistance Publique
Hopitaux de Marseille, Marseille, PACA, France; 4CREATIS; CNRS UMR
5220; INSERM U1044; INSA-Lyon; UCBL, Universit de Lyon, Villeurbanne,
Rhone-Alpes, France
Due to its sensitivity to key processes in the diseased muscle such oedema, inflammation and fatty infiltration, MRI is emerging as a suitable quantitative method which could provide reliable surrogate markers of disease severity and progression. This work investigates the feasibility of a method to distinguish IMAT and SCAT, (ii) to measure muscle relaxation times (T1 andT2*) and to quantify the infiltrated fatty tissue fraction (IFTF) simultaneously. Our approach includes a magnitude-based fat volume fraction quantification method based on multiple-echo multiple angle acquisition with a dedicated automatic segmentation algorithm.