Abstract #0406

Water-Fat MR Imaging for Assessing Changes in Bone Marrow Composition Due to Radiation and Chemotherapy in Gynecologic Cancer Patients

Patrick J. Bolan¹, Luke Arentsen², Thanasak Sueblinvong³, Yan Zhang⁴, Steen Moeller¹, Jori Carter³, Levi S. Downs³, Rahel Ghebre³, Douglas Yee⁴,⁵, Jerry Froelich¹, Susanta K. Hui⁴,⁶

¹Radiology, University of Minnesota, Minneapolis, MN, United States; ²Medical Physics, University of Minnesota, Minneapolis, MN, United States; ³Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN, United States; ⁴Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States; ⁵Department of Medicine, University of Minnesota, Minneapolis, MN, United States; ⁶Therapeutic Radiology, University of Minnesota, Minneapolis, MN, United States

This work demonstrates the feasibility of rapidly acquiring high-resolution 3D signal fat fraction (sFF) maps from mid-femur to the L3 lumbar vertebra, and that the sFF can detect and characterize marrow composition changes induced by chemotherapy and radiation therapy. The marrow fat fraction is potentially an imaging biomarker of bone marrow health and may be useful in planning and monitoring treatment of cancer patients.