Frequency-Domain Quantification and Interpretation of Dynamic Hyperpolarized 13C Signals

Florian Wiesinger¹, Oleksandr Khegai¹, ², Jonathan I. Sperl¹, Eliane Weidl², Axel Haase², Markus Schwaiger², Rolf F. Schulte¹

In this work an efficient and novel frequency-domain signal quantification framework is presented for the analysis and interpretation of dynamically acquired hyperpolarized 13C data. The method is used to compare simple signal normalization versus apparent rate constant estimation for dynamically-acquired, slice-selective FID spectra and IDEAL spiral CS imaging animal rat experiments.