Single-Shot, 2D and 3D Dynamic Imaging of Hyperpolarized 13C Biomarkers in vivo at 14.1 Tesla

Subramaniam Sukumar¹, Simon Hu¹, Peder E. Larson¹, Vickie Y. Zhang¹, Michael Ohliger¹, Robert Bok¹, John Kurhanewicz¹, Daniel B. Vigneron¹

13C imaging using hyperpolarized biomarkers require special pulse sequences to efficiently capture the limited magnetization and to measure the dynamically varying metabolite signals. We developed single shot, 2D and 3D dynamic imaging sequences for selectively observing 13C metabolites at 14.1T. The sequences also address some of the limitations on high field systems, such as, wide spectral width and T2* effects. We have applied these new sequences to acquire dynamic, lactate and alanine images from a mouse cancer model with prostate tumor.