Dustin Kenneth Ragan1, 2, Randall Bateman3, 4, Virginia D. Buckles3, 4, Jose A. Pineda1, 3, John C. Morris3, 4, Tammie LS Benzinger2, 4
1Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States; 2Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States; 3Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States; 4Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, United States
We investigated early changes to cerebral oxygen extraction in patients who had a familiar history of autosomal-dominant Alzheimers Disease by measuring magnetic susceptibility in cerebral veins. Oxygen extraction was showed a decrease around the age of onset, with a return to normal values 5 years after onset. This may indicate an important early marker of the disease process.