Swati Rane1, Tracy Porchak1, Brandon Ally2, Erin Hussey2, Tricia Thornton-Wells3, 4, Shashwath Meda3, John C. Gore1, 5, Manus Donahue1
1Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Neurology, Psychiatry, Vanderbilt University, Nashville, TN, United States; 3Center for Human Genetics Research, Vanderbilt University, Nashville, TN, United States; 4Molecular Physics and Biophysics, Vanderbilt University, Nashville, TN, United States; 5Biomedical Engineering, Vanderbilt University, Nashville, TN, United States
A multi-modal comparison comprising of baseline BOLD and ASL was employed to compare mechanisms of verbal memory deficits in healthy older adults, adults at risk of Alzheimers disease and adults with MCI. Alterations in the default mode network and their correlation with baseline blood flow were studied. Further, synchrony of BOLD fluctuations between the hippocampus and the precuneus/posterior cingulate regions of the brain was evaluated and correlated with verbal memory (CERAD) scores.