M. Vittoria Spampinato1, Ali Tabesh2, Pritesh Topiwala, Muhammad U. Manzoor, Paul Morgan3, Zoran Rumboldt2
1Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States; 2Medical University of South Carolina, United States; 3University of Nottingham
We assessed peritumoral water diffusivity on pretreatment MRI in twenty-one gliomas (low-grade = 5; high-grade =16). Eight VOIs were obtained in 3D ranges away from the tumor VOI (including the tumor and surrounding T2 prolongation) for a distance of 4 cm (5 mm incremental steps). Perifocal normalized mean ADC values were significantly lower in high- than low-grade gliomas 10-25 mm away from the tumor; normalized lowest 25th percentile were significantly lower in high- than low-grade gliomas 10-30 mm away from the tumor. Perifocal ADC measurement in gliomas may reflect the magnitude of tumor infiltration beyond the abnormality on conventional MRI.