Jeffry R. Alger1, David S. Liebeskind1, Noriko Salamon2, Jeffrey L. Saver1, Danny JJ Wang1
1Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 2Radiological Sciences, Geffen School of Medicine at UCLA, Los Angeles, CA, United States
We studied the shape of the residue data that are derived in DSC studies of patients having acute ischemic stroke. Our results indicate that DSC residue data can be modeled as a Gaussian shaped washout function having a half time of 5 8 sec over a wide range of CBF and CBV, including those typically found in ischemic core and penumbra. The absence of a strong relationship between CBF and residue half time indicates that nature achieves higher per unit mass flow rates by increasing the blood volume rather than by increasing the rate of flow through the microvessel system.