Joanna K. Huttunen1, Antti M. Airaksinen1, Artem Shatillo1, Juha-Pekka Niskanen1, 2, Asla Pitknen3, 4, Olli Grhn1
1Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; 3Dept. of Neurobiology, Epilepsy Research Laboratory, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; 4Department of Neurology, Kuopio University Hospital, Kuopio, Finland
The aim of the study was to investigate the origin of the kainic acid (KA) induced epileptic seizures after traumatic brain injury (TBI) utilizing simultaneous local field potential (LFP) and fMRI measurements. In all animals, KA induced seizures caused detectable responses in BOLD and LFP signals. The first epileptic seizure elicited BOLD response initially in the cortex before activating the hippocampus.