Marianne Dorothea Keller1, Nyoman Kurniawan2, Kerstin Pannek1, Stephen Edwards1, Stephen Rose1, Maree Smith1, Elizabeth Coulson1, Ian Brereton1
1The University of Queensland, Brisbane, Qld, Australia; 2The University of Queensland, Brisbane , Qld, Australia
The cholinergic hypothesis states that dysfunction of acetylcholine containing neurons cause the cognitive decline in Alzheimer's disease patients. This project used tractography in a transgenic mouse model (APP/PS1). The transgenic model develops a large Amyloid-β plaque load. We found significant changes due to axonal degeneration of cholinergic fibres that have their origin in the basal forebrain.