Abstract #0667

Assessment of Left Ventricular 2D Flow Pathlines During Early Diastole Using SPAMM-PAV: A Study in Normal Volunteers and Canine Models with Reperfused Infarcts

Ziheng Zhang¹, Daniel Friedman¹,², Donald P. Dione³, Ben A. Lin³, James S. Duncan⁴, Albert J. Sinusas³, Smita Sampath¹

¹Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, United States; ²Department of Mechanical Engineering , University of Pennsylvania School of Engineering and Applied Sciences , philadelphia, PA, United States; ³Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine; ⁴Department of Biomedical Engineering and Diagnostic Radiology, Yale University

The functional mechanisms involved in adverse left ventricular remodeling caused by reperfusion injury are unclear. We have developed a new high temporal resolution MR imaging technique, SPAMM-PAV (SPAtially Modulated Magnetization with Polarity Alternated Velocity encoding) that provides simultaneous regional assessment of flow velocities and myocardial strains during early diastole. Using this method, we performed flow pathline analysis, (1) to study the impact of RI on the nature of filling patterns and (2) to develop a novel index of filling efficiency, characterized by the kinetic energy of flow pathlines during early diastole.