Antti M. Airaksinen1, Joanna K. Huttunen1, Artem Shatillo1, Juha-Pekka Niskanen1, 2, Asla Pitknen3, 4, Olli Grhn1
1Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; 3Department of Neurobiology, Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sci, University of Eastern Finland, Kuopio, Finland; 4Department of Neurology, Kuopio University Hospital, Kuopio, Finland
The aim of the study was to investigate onset region for pentylenetetrazol-induced seizures after traumatic brain injury (TBI) utilizing simultaneous local field potential (LFP) and fMRI measurements. In all animals, PTZ caused detectable responses in BOLD and LFP signals. PTZ induced seizures originate from the periphery of the lesion in 7/13 animals 2 months after TBI and bilaterally in the cortex in all sham operated rats.