Abstract #4269

Quantitative Susceptibility Mapping of Intracranial Tumors: Correlation with Histologic Grade

Krishna Surapaneni¹, Craig Horenstein², Tian Liu³, Cynthia Wisnieff³, Yi Wang⁴, Robert DeLaPaz²

¹Radiology, Columbia University , New York, NY, United States; ²Radiology, Columbia University, New York, NY, United States; ³Biomedical Engineering, Cornell University, Ithaca, NY, United States; ⁴Radiology, Cornell University, NY, United States

Quantitative susceptibility mapping (QSM) is an MRI technique that can determine inherent susceptibility properties of tissues, independent of MRI scan parameters. QSM was performed on 10 patients with primary intracranial tumors; QSM provided complimentary information about the tumors not readily available on conventional SWI images or ADC maps. In this pilot study, the relative change in intratumoral QSM values significantly correlated with histologic tumor grade (r=-0.66, p=0.3). This correlation may reflect differences in magnetic properties of the local tumor microenvironment.