Abstract #4224

Comparison of White Matter Integrity between Alzheimers Disease Patients with & without White Matter Lesions Analyzed by Tract-Based Spatial Statistics

Daniel Han-en Chang^1,2, L. Tugan Muftuler^1,2, Huali Wang³, Orhan Nalcioglu^1,2, Min-Ying Lydia Su^1,2

¹Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; ²Department of Radiological Sciences, University of California, Irvine, CA, United States; ³Department of Geriatric Psychiatry, Peking University Institute of Mental Health, Beijing 10083, China, People's Republic of

The fractional anisotropy (FA) and mean diffusivity (MD) values between subjects diagnosed with major depressive disorder (MDD) and age-matched normal controls (NC) were compared with tract-based spatial statistics. Significant decreases in FA of MDD subjects were found in the inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus of the sagittal stratum and anterior corona radiata. No significant differences were found between MD values. The findings support the hypothesis that MDD may be associated with acute microstructural changes in the white matter of the brain.