Frank M. Skidmore1,2, Mark Yang3,
Lewis Baxter2, Karen von Deneen2, Guojun He2,
Keith White4, Kenneth Heilman5, Mark Gold2,
Yijun Liu2
1Neurology, North
Florida/South Georgia VA Medical Center, Gainesville, FL, United States; 2Department
of Psychiatry, University of Florida, Gainesville, FL, United States; 3Department
of Statistics, University of Florida, Gainesville, FL, United States; 4Department
of Psychology, University of Florida, Gainesville, FL, United States; 5Department
of Neurology, University of Florida, Gainesville, FL, United States
We wished to evaluate if resting state fMRI could identify individuals with Parkinson disease (PD_. Analyzing the resting state and using a cross-validation approach, we were able to separate individuals with PD from controls with a 92% sensitivity and 86% specificity. Our work shows proof of concept for use of fMRI as a biomarker technique for identification of PD.