Reproducibility of Apparent Diffusion Coefficient Values at Hippocampus Measured by High-Resolution Readout-Segmented DWI vs. Single-Shot DWI with 2DRF Excitations.

Ryo Sakamoto¹, Tomohisa Okada¹, Akira Yamamoto¹, Mitsunori Kanagaki¹, Seiko Kasahara¹, Emiko Morimoto¹, Mami Iima¹, Satoshi Nakajima¹, Taha Mohammed Mehemed¹, Kaori Togashi¹

Clinical applications of ADC measurement for disorders involving hippocampus are highly important. It requires reasonable reproducibility in acceptable scan time. In single-shot EPI, 2D-RF excitations enables reduced FOV, and less distorted DWI (2DRF-DWI) can be obtained. For multi-shot EPI, readout-segmented EPI can be used for DWI measurement (RS-DWI). These two methods gave highly reproducible CV values of ADC: 1.82 } 1.12 and 2.42 } 1.36 %, respectively for RS-DWI and 2DRF-DWI. However, ADC values at hippocampus were 0.881} 0.027~10-3 mm2/s and 0.463 } 0.039~10-3 mm2/s, respectively, and the latter resulted from low SNR in 2DRF-DWI.