Abstract #4112

Evaluation of T1 & T2* Mapping Reproducibility at 3T using Histogram Analysis

Christopher Glielmi¹, Ryan Hutten², Shawn Sidharthan², Hongyan Du², Todd Parrish³, Ann Ragin⁴, Robert R. Edelman², Ying Wu²

¹Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, United States; ²NorthShore University HealthSystem, Evanston, IL, United States; ³Biomedical Engineering, Northwestern University, Chicago, IL, United States; ⁴Radiology, Northwestern University, Chicago, IL, United States

T1 and T2* mapping are useful approaches to detect and monitor degenerative brain diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). However, reproducibility between repeated measures must be evaluated for clinical studies involving serial scanning. This study explores reliability and reproducibility of various histogram analysis metrics for T1 and T2* mapping in healthy subjects at 3T. Specifically, focus is on subcortical regions relevant to neurodegenerative diseases such as PD and AD.