Abstract #3459

3D Cartesian Volumetric Liver Perfusion MRI with High Temporal & Isotropic Spatial Resolution

Kang Wang¹, Frank Korosec¹, Yin Huang¹, Kevin Johnson¹, Ethan Brodsky², Reed Busse³, James Holmes³, Jean Brittain³, Scott Reeder^1,4

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; ²Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; ³Global Applied Science Laboratory, GE Healthcare; ⁴Radiology, University of Wisconsin-Madison, Madison, WI, United States

MR liver perfusion is a non-invasive imaging method to assess of the blood supply to liver tumors, providing quantitative measurements of the early changes in liver tumor microvascularity with chemotherapy that may predict long-term tumor response. However, quantitative liver perfusion has been challenging due to the requirement for entire liver coverage, high spatial and high temporal resolution. The purpose of this study is to demonstrate the feasibility of overcoming these technical challenges using a previously developed Interleaved Variable Density sampling method with parallel imaging and Cartesian HYPR reconstruction.