Abstract #3458

Cerebral Blood Volume Fraction Quantification in Mice

Teodora-Adriana Perles-Barbacaru¹, Francois Berger², Hana Lahrech¹

¹INSERM U836, Functional & Metabolic Neuroimaging, Grenoble Institute of Neurosciences, University Joseph Fourier, Grenoble, France; ²INSERM U836, Brain Nanomedicine Group, Grenoble Institute of Neurosciences, University Joseph Fourier, Grenoble, France

Noninvasive quantification of regional cerebral blood volume fraction (BVf) by magnetic resonance (MR) imaging can be used to map brain dysfunction and to monitor drug efficacy in patients and in preclinical studies. This study demonstrates that the Rapid Steady State T₁ MR technique, previously used with intravenous contrast agent injections in rats, can be used with intraperitoneal injections of Gd-DOTA to safely and reliably acquire cerebral BVf maps in mice during a comfortable time interval of at least 20 minutes.