Asif Rizwan1, Inna Serganova2, Xiaohui
Ni1, Sunitha Thakur1,3, Ronald Blasberg2,3,
Jason Koutcher1,4
1Medical Physics, Memorial
Sloan-Kettering Cancer Center, New York, NY, United States; 2Neurology,
Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 3Radiology,
Memorial Sloan Kettering Cancer Center, New York, NY, United States; 4Radiology,
Memorial Sloan Kettering Cancer Center, New York, NY, United States
Metabolic changes in primary tumors are recognized to have a significant impact on the development of metastatic phenotypes. The accumulation of lactate in tumors is associated with aerobic glycolysis. The objective of this study was to compare lactate production in non-metastatic (67NR) and metastatic (4T1) orthotopic implanted murine breast tumors. The spectra are acquired using the selective multiple-quantum coherence transfer (SelMQC) sequence. The 4T1 tumors show a high level of lactate at the early stage of growth while 67NR tumors have barely detectable lactate signal. These results show that lactate can be used as a prognostic marker for tumor metastasis