Asif Rizwan1,2, Xiaohui Ni1,
Rachael O'Connor3, Samuel Singer3, Jason Koutcher1,4,
Kristen L. Zakian1,4
1Medical Physics, Memorial
Sloan-Kettering Cancer Center, New York, NY, United States; 2Weill
Cornell Medical College, New York, NY, United States; 3Sarcoma
Biology Laboratory, Sarcoma Disease Management Program & Surgery,
Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 4Radiology,
Memorial Sloan-Kettering Cancer Center, New York, NY, United States
Liposarcoma is the most prevalent type of soft-tissue sarcoma (STS), comprising 20% of that heterogeneous tumor family. Dedifferentiated liposarcoma (DDLS) is an aggressive STS subtype with 5-year disease-specific survival of 44%. Not only is there a need for more effective treatment for this potentially deadly tumor, but additional a priori prognostic information would be useful in identifying patients needing more aggressive treatment. The goal of the current study was to assess the glycolytic phenotype in two models of DDLS using lactate-edited MR spectroscopic imaging.