Abstract #3153

Differentiation of Radiation Necrosis from Glioma in Rat Models using Diffusion Tensor MR Imaging

Silun Wang¹, Yifei Chen¹, Bachchu Lal^2,3, Eric Ford⁴, Erik Tryggestad⁴, Michael Armour⁴, Kun Yan¹, John Laterra^2,5, Jinyuan Zhou^1,6

¹Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States; ²Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States; ³Neurology, Kennedy Krieger Institute, Baltimore, MD, United States; ⁴Radiation Oncology, Johns Hopkins School of Medicine, Baltimore, MD, United States; ⁵Neurology , Kennedy Krieger Institute, Baltimore, MD, United States; ⁶F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We evaluated the DTI features of brain radiation necrosis (40 Gy, 1010 mm2) and 9L and GBM22 glioma models in rats. Results indicated that radiation necrosis consisted of a hyperintense rim and a hypointense central zone, compared to the contralateral hemisphere. There was decreased directionality and magnitude of water diffusion in the lesion of radiation necrosis, particularly in its central zone. Qualitative and quantitative analysis of DTI indices provides useful information to differentiate between radiation necrosis and glioma in rat models.