Abstract #3109

Effect of Anesthesia on Tumor Vascular Permeability Measurements by DCE-MRI

Wenlian Zhu¹, Yoshinori Kato¹, Dmitri Artemov¹

¹The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University, Baltimore, MD, United States

Anesthesia is an essential and yet often overlooked component of preclinical DCE-MRI study. The goal of this study is to investigate whether anesthesia method has any effect on the tumor vascular permeability measurements by DCE-MRI with a macromolecular contrast agent, albumin-(DTPA-Gd) in human breast cancer MCF-7 mouse xenografts. Preliminary results from mice anesthetized by isoflurane alone, and a combination of ketamine/acepromazine induction and isoflurane maintenance are reported here.