Seung-Cheol Lee1, Harish Poptani1,
Hari Hariharan1, Sunita Nasta2, Jakub Svoboda2,
Stephen J. Schuster2, Jerry D. Glickson1
1Department of Radiology,
University of Pennsylvania, Philadelphia, PA, United States; 2Department
of Medicine, Hematology Oncology Division, University of Pennsylvania,
Philadelphia, PA, United States
1H MRS and MRI methods (Lactate, total choline and ADC) were applied to detect therapeutic response in non-Hodgkin's lymphoma patients. Recently developed Hadamard slice-encoded selective multiple quantum coherence chemical shift imaging sequence was used for localized detection of lactate. PRESS and diffusion-weighted EPI were used for tCho and ADC measurements. Lac and tCho decreased after treatment while ADC increased. A 3T scanner was used.