Abstract #2988

The Effect of Gd-DTPA on the Determination of the Apparent Diffusion Coefficient in Liver Metastases & Healthy Liver Tissue

Ulrike Fasol¹, Klaus Mross², Annette Frost², Martin Buechert¹, Valerij Kiselev¹, Juergen Hennig¹

¹MR Development & Application Center, University Medical Center Freiburg, Freiburg, Germany; ²Tumor Biology Center, Albert-Ludwigs-University Freiburg, Freiburg, Germany

Using the Apparent Diffusion Coefficient (ADC) as a biomarker for tumors under therapy is currently under investigation. In most studies contrast enhanced imaging is included in the protocol, which poses the problem of the influence of the contrast agent on the determination of ADC. Studies performed till now were mainly focused on measurements in the brain. We present results for the effect of contrast agent on the ADC measurements in normal liver tissue and metastasis at 1.5 T.