Abstract #2411

Evaluation of Changes in Gliomas Structural Features After Chemotherapy using DTI-Based Functional Diffusion Maps (FDMs): A Preliminary Study with Intraoperative Correlation.

Antonella Castellano¹, Marina Donativi^2,3, Lorenzo Bello⁴, Giorgio De Nunzio^2,3, Marco Riva⁴, Gabriella Pastore², Giuseppe Casaceli⁴, Roberta Rud⁵, Riccardo Soffietti⁵, Giuseppe Scotti¹, Andrea Falini¹

¹Neuroradiology Unit & CERMAC, Scientific Institute & University Vita-Salute San Raffaele, Milan, Italy; ²Department of Materials Science, University of Salento, Lecce, Italy; ³INFN (National Institute of Nuclear Physics), Lecce, Italy; ⁴Neurosurgery, Department of Neurological Sciences, University of Milano, Milan, Italy; ⁵Neuro-Oncology, Department of Neuroscience & Oncology, University of Torino, Turin, Italy

fDMs analysis was applied to diffusion tensor decomposition-derived isotropic (p) and anisotropic (q) maps during neuroradiological follow-up of patients undergone to chemotherapy before surgery; changes in diffusion parameters within tumor tissue were correlated both with neurophysiological data from intraoperative subcortical mapping and histopathological findings from specimens obtained from image-guided tumor biopsies. The proposed DTI-based method, when benchmarked against morphologic imaging criteria, seems to provide an indication of response to treatment prior to alteration in size.