Abstract #2410

CIMPLE Maps Derived from Serial Diffusion MR Images in Recurrent Glioblastoma Treated with Bevacizumab

Benjamin M. Ellingson¹, Timothy F. Cloughesy², Albert Lai², Phioanh L. Nghiemphu², Whitney B. Pope¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; ²Neurology, University of California Los Angeles, Los Angeles, CA, United States

Identification and quantification of spatially-localized brain regions undergoing high rates of tumor cell migration and proliferation is critical for improving patient survival. CIMPLE (cell invasion, motility, and proliferation level estimates) image maps from serial diffusion MRI represent a novel method of quantifying the level of aggressive malignant behavior. In the current study, we demonstrate the utility of CIMPLE maps to predict regions of future contrast-enhancement and stratify short and long-term progression free survival (PFS) and overall survival (OS) in recurrent glioblastoma patients treated with bevacizumab.