Abstract #2401

Dose Dependence of T1 & Phase Contrast Following Mn2+ Systemic Administration at 14.1T

Rajika Maddage¹, Jos Pedro Marques^2,3, Rolf Gruetter^2,4

¹Laboratory for Functional & Metabolic Imaging , Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; ²Laboratory for Functional & Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland; ³Department of Radiology, University of Lausanne, Lausanne, Switzerland; ⁴Department of Radiology, University of Lausanne & Geneva, Switzerland

At high magnetic field, phase imaging has proven to be a potential tool to trace Mn²⁺ enrichment in MEMRI. The aim of the study was to investigate the contrast enhancement as a function of Mn²⁺ dose to assess the sensitivity of T₁-W and phase imaging at 14.1T. Results show that at the lowest dose of 75mg/kg, the contrast observed in the phase image remains strong with clear depiction of various anatomical structures further supporting the notion of phase imaging's high sensitivity to magnetic susceptibilities and more importantly [Mn²⁺].