Simon Sean Keller1, Tobias Ahrens1,
Siawoosh Mohammadi2, Gabriel Mddel1, Harald Kugel3,
Bernd Weber4, E. Bernd Ringelstein1, Michael Deppe1
1Department of Neurology, University
of Mnster, Mnster, Germany; 2Wellcome Trust Centre for
Neuroimaging, University College London, United Kingdom; 3Department
of Radiology, University of Mnster, Mnster, Germany; 4Department
of Epileptology, University of Bonn, Germany
In this diffusion tensor imaging study, we show that patients with temporal lobe epilepsy with unknown cause (TLEu) have significant diffusion abnormalities of temporal lobe structures ipsilateral and contralateral to the side of seizure onset relative to age and sex matched neurologically healthy controls. We further show that bilateral parahippocampal and thalamic abnormalities correlate with the duration of TLEu.