Abstract #2283

Anatomical Phenotyping of the PML Knockout Mouse

Benjamin Sinclair^1,2, Jon Cleary², Joanne Henderson³, Marc Modat¹, Francesca Norris^2,4, Paolo Salomoni³, Sebastien Ourselin¹, Mark Lythgoe²

¹Centre for Medical Image Computing, UCL, London, United Kingdom; ²Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom; ³UCL Cancer Institute, London, United Kingdom; ⁴Centre for Mathematics & Physics in the Life Sciences & EXperimental Biology (CoMPLEX)

This study applies MRI and image processing techniques to a mouse model with a knockout of the PML gene, which has known links with tumour suppression and neurogenisis.