Abstract #2194

Effects of Apolipoprotein E-Epsilon 4 Genotype on the Functional Brain Networks Implicated in Cognition in Healthy Middle-Aged Adults

Joseph Goveas¹, Chunming Xie^2,3, Gang Chen², Wenjun Li², B. Douglas Ward², Guangyu Chen², Jennifer Jones⁴, Malgorzata Franczak⁴, Piero Antuono⁴, Shi-Jiang Li²

¹Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States; ²Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ³Neurology, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China, People's Republic of; ⁴Neurology, Medical College of Wisconsin, Milwaukee, WI, United States

Apolipoprotein E-&4 (ApoE-&4) carriers are at an increased risk for incident late-onset Alzheimers disease (AD). While diminished default mode network (DMN) functional connectivity is observed in AD, increased DMN connections to medial and dorsolateral prefrontal cortices and medal temporal lobe regions, and decreased connectivity to precuneus are reported in ApoE-&4 carriers. We examined if ApoE-&4 carriers will show alterations in the DMN, executive control (ECN) and salience networks (SN), relative to ApoE-&4 non-carriers.