Abstract #2193

Characterize the Distribution & Behavior Significance of the Global Signal Measured by Resting-State Functional Connectivity in the Elderly

Guangyu Chen¹, Chunming Xie¹, Gang Chen¹, Barney Douglas Ward¹, Wenjun Li¹, Piero Antuono², Shi-Jiang Li³

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ²Neurology, Medical College of Wisconsin, Milwaukee, WI, United States; ³Psychiatry & Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI, United States

The correlation between global signal and all brain voxel's time series which are not regressed out the global signal can reveal the distribution pattern of global signal in brain. The significant correlation between global signal distribution and behavior score such as Geriatric Depression Scale (GDS) and Rey Auditory Verbal Learning Test (RAVLT) indicates that global signal has biological significance. And we found that the different distribution pattern between healthy and mild cognitively impaired brain is primary overlapped with default mode network.