Yanming Yu1, Quan Jiang2, Haoyu
Wang3, Shanglian Bao3, E. Mark Haacke4,
Jiani Hu4
1Logging Technique Research
Iinstitute, great wall drilling company, China National Petroleum Corporat,
Beijing, China, People's Republic of; 2Department of Neurology,
Henry Ford Health Sciences Center, Detroit, MI, United States; 3Beijing
Key Lab of Medical Physics & Engineering, Peking University, Beijing, China,
People's Republic of; 4Department of Radiology, Wayne State
University, Detroit, MI, United States
The purpose of this project is to investigate the effect of T2* on permeability and effect of T1 on perfusion using a new pharmacokinetic model with simultaneously acquired T1 and T2* DCE-MRI data. The preliminary results demonstrate that 1) T2* has great effects on the estimation of permeability parameters; 2) T1 has great effects on the estimation of perfusion parameters; 3) both the T1 and T2* effects are much greater in tumors when compared to healthy brain tissue. In conclusion, simultaneously acquired T1- and T2*-weighted DCE-MRI data can be used to improve the estimation accuracy of permeability and perfusion parameters.