Abstract #2059

A Dynamic Lesion Phantom for Quantitative Evaluation of Dynamic Contrast Enhanced MRI

Melanie Freed^1,2, Jacco A. de Zwart³, Prasanna Hariharan⁴, Matthew R. Myers⁴, Aldo Badano¹

¹CDRH/OSEL/DIAM, Food & Drug Administration, Silver Spring, MD, United States; ²Dept. Bioengineering, University of Maryland, College Park, MD, United States; ³Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States; ⁴CDRH/OSEL/DSFM, Food & Drug Administration, Silver Spring, MD, United States

There is a need for realistic and well-characterized dynamic phantoms for dynamic contrast-enhanced MRI of the breast to aid in optimization and standardization of imaging protocols. We have developed a dynamic lesion model that mimics the border shape and washout curve behavior of benign and malignant breast lesions. Measurements of the true contrast agent concentration versus time were acquired with an x-ray system and compared with MRI measurements using different spatial and temporal resolutions.