Abstract #1372

Free-Breathing T1 Mapping MRI for Quantification of Myocardial T1 Pre & Post Contrast in Swine with Non-Ischemic Heart Failure

Maureen N. Hood^1,2, Ting Song^1,3, Peter Bedocs⁴, John Capacchione⁴, Mark Haigney^5,6, Christine E. Kasper⁷, Vincent B. Ho^1,2

¹Radiology, Uniformed Services University, Bethesda, MD, United States; ²Radiology, National Naval Medical Center, Bethesda, MD, United States; ³Global Applied Science Laboratory, GE Healthcare, Bethesda, MD, United States; ⁴Anesthesiology, Uniformed Services University, Bethesda, MD, United States; ⁵Medicine, Uniformed Services University, Bethesda, MD, United States; ⁶Cardiology, National Naval Medical Center, Bethesda, MD, United States; ⁷Graduate School of Nursing, Uniformed Services University, Bethesda, MD, United States

MRI may offer a non-invasive tool to quantify the degree of fibrosis in patients with diffuse disease by taking advantage of the inherent T1 values of tissues. Purpose of this study is to investigate a new free-breathing pulse sequence to quantify myocardial T1 changes in tachycardia-induced heart failure in swine and to investigate T1 value changes after administration of a gadolinium-chelate. T1 mapping results were compared to traditional myocardial delayed enhancement as well as to control and heart failure histological tissue samples.