Association of the Apparent Diffusion Coefficient of Bladder Cancer with Metastatic Disease: Preliminary Results

Thais C. Mussi¹, Bradley Spieler¹, Andrew B. Rosenkrantz¹

19 patients with urothelial carcinoma of the bladder who underwent MRI including DWI at 1.5T were included. Among these, 8 had nodal or distant metastatic disease, and 11 had an absence of metastatic disease (mean follow-up 434 days). ADC was measured for each lesion and was significantly lower among those cases with metastatic disease (p=0.0012). Using ADC for prediction of metastatic disease, ROC analysis identified an AUC of 0.920, sensitivity of 87.5%, specificity of 100%, PPV of 100%, and NPV of 91.7%.