Treatment Effects of Diffuse Intrinsic Pontine Gliomas On Tumor & Normal Appearing Cortical Gray Matter Assessed By Arterial Spin Labeling Perfusion & 3D Volumetric Measurements

Jan Sedlacik^1,2, Claudia M. Hillenbrand¹, Alberto Broniscer³

In a clinical trial of combined antiangiogenic and local radiation therapy (RT) of brainstem gliomas changes in tumor and cortical grey matter (GM) perfusion were closely monitored by arterial spin labeling and volumetric measurements. Median tumor perfusion was found to be increased and showing a higher variance directly after RT suggesting different tumor responses to treatment compared to tumor volume which decreased in all patients. A temporary drop in cortical GM perfusion and volume was found directly after baseline which may be caused by steroids, given at the beginning of therapy.