Catherine Anusha Mallik1, Gareth J. Barker1,
David J. Lythgoe1
1Centre for Neuroimaging Sciences,
Institute of Psychiatry, London, United Kingdom
Correlation
of quantitative MRI with brain iron may prove a useful tool in the diagnosis
and prognosis of associated neuropathology. Sequences required for three of
the most promising measures were implemented: transverse relaxation rate,
magnetic susceptibility and magnetic field correlation (MFC) mapping.
Protocols for each technique were standardised for brain coverage under the
constraint of approximately equal, patient tolerable, scan times. Data
collected on three control subjects at 3T in six brain regions indicated that
magnetic susceptibly is the most closely correlated with reference brain iron
of the three techniques.