Abstract #4838

Detection and Improvement of Anti-Angiogenic Therapeutic Efficacy by Using Hemodynamic Response Imaging in Mice

Yifat Edrei^1,2, Eitan Gross³, Nathalie Corchia¹, Elia Dery¹, Shmuel Ben-Sasson⁴, Rinat Abramovitch^1,2

¹The Goldyn Savad Inst. for Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel; ²MRI/MRS lab HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel; ³Pediatric Surgery, Hadassah Hebrew University Medical Center; ⁴Experimental Medicine & Cancer Research, The Hebrew Universioty Hadassah Medical School

Since anti-angiogenic therapies may not lead to substantial tumor shrinkage, their effect is better imaged using perfusion imaging rather than tumor size measurement. Recently, we demonstrated the feasibility of Hemodynamic Response Imaging (HRI), an fMRI method combined with hypercapnia and hyperoxia, for monitoring changes in liver perfusion and hemodynamics. Here we show that a novel anti-angiogenic drug (Hamsa) reduces colorectal liver metastases growth and thus prolong mice survival. We assessed the therapeutic efficacy by HRI and revealed two types of response. By utilizing HRI we revealed the underlying mechanisim of Hamsa potential which hopefully would improve the Hamsa therapeutic potency.