Na Zhang1,2, Zhengsheng Deng2, Li
Meng3, XiaoYi Wang3, Weihua Liao3, Bob L.
Hou4
1Paul C. Lauterbur Research Center for
Biomedical Imaging,Paul C. Lauterbu, Chinese Academy of Science , Shenzhen, Guangdong,
China; 21Institute of Biomedical Engineering, School of
Info-physics and Geomatics Engineering,, Central South University, Changsha,
Hunan, China; 3Department of Radiology, XiangYa Hospital of School
of Medicine, Central South University, Changsha, Hunan, China; 4Radiology,
West Virginia University, Morgantown, WV, United States
The
breakdown of blood-brain barrier (BBB) in gliomas results in the increment of
microvascular permeability: a surrogate marker to assess malignant degree of
gliomas. The volume transfer coefficient of contrast agent (CA) from plasma
space to extravascular extracellular space (EES), as defined Ktrans, has been
used to characterize the microvascular permeability quantitively. Since
knowing the grades of gliomas for administration of the tumor treatments is
very important, and there were only few reports for applying T1 perfusion MRI
data for evaluating grades of glioma, in current study we presented the
results of correlation of Ktrans and histopathologic grades of gliomas by
using the T1-weighted dynamic contrast enhancement magnetic resonance imaging
(DCE-MRI) method and a modified Tofts' model, and also investigated to apply
Ktrans, Kep, Kel, Ve, and Vp obtained from the T1 perfusion data analyses for
evaluating grades of the gliomas.