Ted Trouard1,2, Patricia Thompson3,
Chuan Huang4, Maria Altbach2, Matthew Kupinski2,
Denise Roe3, Kimberly Fitzpatrick2, Per Granstrom2,
Georgette Frey3, Scott Squire2, Veronique Poulin3,
Alison Stopeck3
1Biomedical Engineering, University of
Arizona, Tucson, AZ, United States; 2Radiology, University of
Arizona, Tucson, AZ, United States; 3Arizona Cancer Center,
University of Arizona; 4Mathematics, University of Arizona
Breast
density, as measured by mammography, is associated with elevated risk of
breast cancer. Decreases in
mammographic breast density have also been linked with beneficial effects of
chemoprevention. However, the low
precision and reproducibility of mammography, as well as exposure to ionizing
radiation, limits the use of mammographic breast density as a biomarker for
risk and prevention. In this study we
have employed Fat Water Ratio (FWR) MRI for assessment of breast density and
compared the results to conventional mammography and to apparent diffusion
coefficients (ADCs) measured by diffusion-weighted (DW) MRI.