Ian J. Tagge1, Xin Li1, Luminita
Alina Tudorica1, Yiyi Chen1, Stephanie Hemmingson1,
Elizabeth A. Morris2, Charles S. Springer1, Wei Huang1
1Oregon Health & Science
University, Portland, OR, United States; 2Memorial Sloan Kettering
Cancer Center, New York, NY, United States
High
temporal-resolution research DCE-MRI data from 66 suspicious breast lesions
were resampled to mimic typical clinical protocols with low
temporal-resolution. The Standard
Model (SM) and Shutter-Speed Model (SSM) pharmacokinetic analyses show that
both Ktrans and Ktrans [ Ktrans(SSM) C Ktrans(SM)] are significantly
underestimated at the lower temporal resolution, and the diagnostic
accuracies of both parameters are considerably compromised.