Clinical Significance of the 2 Ppm Resonance in In-Vivo 1H-MR Spectroscopy of Ovarian Tumors

Mayumi Takeuchi¹, Kenji Matsuzaki¹, Masafumi Harada¹, Hiromu Nishitani¹

We evaluated 31 ovarian tumors including 8 mucinous tumors by 1H-MR spectroscopy at 3T. High to moderate 2 ppm peaks were observed in all 8 mucinous tumors, whereas low to slight 2 ppm peaks were observed in 14 of 23 non-mucinous tumors. The 2 ppm concentration in mucinous tumors (7.39+/-2.85 mM) was significantly higher than that in non-mucinous lesions (3.12+/-1.42 mM) (p<0.005). Using a cut off value of 4.45 mM for mucinous tumors had a sensitivity of 88%, specificity of 86%, PPV of 78%, and NPV of 92%.