Michael K. Liem1, Saskia A.J. Lesnik
Oberstein2, Maarten J. Versluis1, Joost Haan3,
Andrew G. Webb1, Michel D. Ferrari3, Mark A. van Buchem1,
Jeroen van der Grond1
1Radiology, Leiden University Medical
Center, Leiden, Netherlands; 2Clinical Genetics, Leiden University
Medical Center, Leiden, Netherlands; 3Neurology, Leiden University
Medical Center, Leiden, Netherlands
In
this study we examined luminal diameters of lenticulostriate arteries in
patients with cerebral autosomal dominant arteriopathy with subcortical
infarcts and leukoencephalopathy (CADASIL). Twenty-two CADASIL patients and
11 controls were examined using high resolution 3D-time-of-flight magnetic
resonance angiography (TOF MRA) imaging on a 7-Tesla MRI scanner. No differences
between CADASIL patients and controls were found in length, total number or
total cross-sectional area of lenticulostriate artery lumina. Measurements of
lenticostriate arteries were not associated with lacunar infarct load in the
basal ganglia area.